Brown University Division of Renal Diseases
نویسندگان
چکیده
MELAS (mitochondrial encephalomyopathy with lactic acidosls and stroke-like episodes) is one of a group of heterogeneous yet clinically distinct syndromes ascribed to a defect in mitochondrial function. Here, the case of a patient diagnosed with the 1 Received November 21, 1994. Accepted October 19. 1995. 2 Correspondence to Dr. L Dworkin, Division of Renal Diseases, The Rhode Island Hospital, 593 Eddy Street, Providence, RI 02806. 1046.6673/0705.0647$03.00/0 Journal of the American society of Nephrology Copyright C 1996 by the American society of Nephrology MELAS syndrome who subsequently developed acute renal failure is reported. Although no clear renal insult was evident at the time, the clinical picture was consistent with the diagnosis of acute tubular necrosis. The patient’s renal function subsequently returned to baseline. This article reviews the literature concerning renal Involvement in the mitochondrial encephalomyopathies, including MELAS, and proposes a mechanism by which patients suffering from mitochondrial disorders may be more susceptible to renal hypoxic Injury and acute renal failure.
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